I'm running a 100% POTD playthrough now with my PC Barbarian with max str and int and going for 2h build. Forgegloves early on and soulbound weapons towards the end game. Been using Aloth, Eder, Durance, Kana and Pallegina. Eder is my main tank and Pallegine works as off tank/secondary melee dps, Kana and Durance and Aloth are all range, though Aloth is the powerhouse as far as range damage goes. Worked well so far, just finished White March part 1 and done everything but the last part of the act 2 main story. So far its been pretty easy as far as fights go.