As I read the topic I instantly wanted to say 'POST APOC!!11', but when I think about it, the type of setting doesn't really matter that much to me. As long as the game world is presented in a believable and interesting way, ANY setting can be fun. I don't like unimaginatively ripped off setting implementations ("They might look like dragons but in this game, they're called 'ZROGGS'!"; "No, it's not Mana, it's 'Bluebarontheright'.") or when you can clearly tell that parts of the game world were altered or designed only to serve a certain pc-related gameplay aspect (stuff like healing/mana wells or shrines, those ability upgrade canisters in GeneForge or the floating bubbles in Lionheart, which were just there to be absorbed by you). I especially hate that when the explaination sucks or isn't given at all.
I don't see why people who are sick of standardized fantasy settings are screaming for cyberpunk though. Maybe it's because I don't know much about that matter, but isn't cyberpunk just fantasy in a different, preferably dark blue color scheme, with magic replaced by PSI?