I'd love to see Obsidian doing an action-oriented (read: not FPS) RPG in the vein of Deus Ex, Omikron or Beneath a Steel Sky. Something Cyperpunky with a mix of utopian future horrors, some Noir, some Japanese Giant Robots and lots of kewl MCA humor! On top of that, some of uncle Feagies lovely dried sweat to add some aroma and just to remeber us how much we still love you, Obsidian!
But for loves sake, please do a break for DnD after NWN2!