Same things happening to me. Initially entered through the roof down into the Sanctuary, cleared the Sanctuary but didn't have the mechanic skill to get into the two locked rooms. So I went down into the dungeon and cleared that, just talked to the crazy lady and was headed back up to the Sanctuary level, but when I got out into the main level and went to click on the stairs in the kitchen to go back up, the game loaded to a black screen and a movement cursor. I'm stuck right now, all my saves seem to be doing the same thing and I don't have any more recent saves than down in the dungeon.
Everything was going smoothly, not a single bug and now I'm really sad because I'm stuck because of this.
edit - To add to this. Entering the Sanctuary level from any of it's points leads to the black screen with movement cursor and followed by the game crashing. This is really disappointing