I would think so. Other than Dante and Nero having white hair and all of the characters wearing wacky outfits (e.g. Lady and Trish), it doesn't really look like anime. The story is standard anime-fare, but I think that has more to do with Japan than anime itself. The characters are pretty entertaining, with the exception of Kyrie in the role of the Japanese-style personality-less young woman.
okie dokie, maybe it's just me, but i really don't see how that picture of Trish is wacky...
It's not just you, I also know a few people with outfits like that
maybe we're just the weird ones on this board haha
i mean, you with your piercings, me with my odd fascination with body mods