AC is something what is not the best described, but is used since the 1st D&D and it would be hard to change it (they try that in 3.5, but its not worked out)
I have used Smoothtalk (dont remember skill names correctly) ,matrial arts,
Plasma weapon and have used a plasma gun-sniper variant
(just think of hitting the enemy from one side of the screen in
the other AND precisely in eye )
Throwing has to have its own skill, maybe not just throwing weapons (think of a HUGE mutant throwing automobiles, or a knight a two-hand claymore :D )
More variable armor would be nice, but i like power armors
(but there r not just strenght modefier, some could change speed,agility,dodge,reflexes.Like exoskeletals in KOTOR)
...
besides, Bethesda guys are working on Fallout3, but i don't think it comes
out before 2010