Cloverfield. I'm going to rewatch it here in a bit, but my first reaction was, well, wow. I can see how some people won't like the whole shot-on-hand-cam thing, but a few minutes after the fit hits the shan I barely seemed to notice and just accepted it for what it was.
I would have liked a few more answers as to what the hell that thing was, but I guess they need to leave something for the sequel.
I'll give this show eight and half squid tentacles out of ten translucent eyes.