If Project Eternity is supposed to be harkening back to the IE days, then keep lockpicking "mini games" out. I don't like then to start with, but they go against the status quo of attempting to give a reasonable simulation of actual pencil and paper roleplaying.
In my opinion anything that takes more skill than opening a door needs a skill check. The stats are there for a reason: they define what your character can and can't do. Turning on a sink tap takes no skill, so there's no check. Fixing the tap if it's broken takes more skill than normal, so there should be a skill check. The same idea should be the same for lockpicking. It's a skill...so there needs to be a check.
Even with Bethesda's skill systems it's still entirely possible for a player to whiz through master level locks if they're good enough at the mini game. Is it possible for someone with some basic lockpicking knowledge to occassionally get lucky and slip open a tricky lock? Sure. Even a blind horse finds water every once in a while. So if you happen to get a lucky roll, then you get lucky.
Let's let Obisidian spend more time crafting great dialogue, events, and player choices. Let's not see them spend time implementing minigame features that aren't required.