ah right, specifically those 2 dudes with the swords and the funny spell? I havn't fought the other lady yet, their Chinatown leader, just about to (if I can pull myself away from HL2)
anyways, I mostly killed those guys with blood boil and blood shield basically gave me the time to do it. First time I think I had to hit up my blood packs too. I don't recall being worried about dying tho.
If the challenge was to kill them with my barehands, without spells, then I guess if I go against my build the combat might be difficult.... <_<
I think the most challening part of the whole game, definatly the section where I died the most, is that walkway over by Gary that is over a pit of acid. There is a section off it, where it hooks and dibs, I always fell off. Not sure if it is a bug, bad level design, or just tricky for me but I died like 3 times there. As there is no way to get out of the pit I can find. I have to crouch and inch forward to get past it with certainty.