Rare's Banjo-Threeie on the XBox360.
NWN2's Next Expansion, considering that MotB granted absolutely no freedom at all, and there were barely any side quests whatsoever. And I like Freedom, like Baldur's Gate 1+TotSC/2, (excluding the Expansion, since there wasn't too much freedom and side-quests there, but there was still MORE than MotB, which is pretty bad)
Fable 2 on the PC/XBox360, either and both, because it is not sure if it will ever come out on the PC, yet, the original did, so I'm guessing it eventually will.
The Elder Scrolls V, (I don't even know if it will ever come out, but my guess is that it will, since Oblivion and Morrowind have such huge modding communities, and they had a huge number of buyers for both games and expansions).
Blizzard's Diablo 3 on the PC.