So barring any built-in melee adjustments based on class....
A wizard with 18 str and a great sword will do more damage than a 12 str fighter, yes? And with higher Perception, will hit with greater %?
I don't necessarily hate it. There are some spells that allow for wizard melee-ing. Even Gandalf wielded a sword sometimes... But with interrupts as they are, probably not the best idea.
I would rather that than any sneaky built-in code that let certain classes hit more or with higher damages.