I have experienced the same crash. Sometimes it happens before the loading screen but usually after with a black screen and "Pillars of Eternity is not responding" message from windows. I have tried to get around it many times but it repeats with different transition areas in Raedric's keep.
I also have a bugged character on a completely new game started from scratch where a character constantly runs on the spot unless you move her specifically (a barb) - now the game has frozen because she is still running on the spot after enemies are dead and combat does not end because she is stuck.
My specs are Win7 Ultimate(64), Nvidia GTX560Ti, 6gig ram, i7920 processor. I am playing the Steam version and anyone who wants to observe either bug is welcome to request a broadcast observation.
It's very frustrating because until everything turned to mush I was loving the game. (and reviewed it at 98%)