I have played for a few hours, and almost all stuff I find, I can pick up. There's one big exception, though: beetle shells. It's impossible, and they respawn all the time, when I re-enter maps within a gaming session. I don't get duplicates, but those that gets pseudo-picked up (their loot icon disappears, but no item in invo), will be replaced with a new fake loot icon with an "un-pick-uppable" beetle shell.

Hey IndiraLightfoot, just to let you know, those are two separate issues, but both are known and in the works. First, beetle shells are ingredients, so they're being placed in a (currently hidden) inventory that should be viewable later. Second, the reappearing loot bags is a known issue that is being looked into. Keep up the good work!