Wow, pushed back to page three by all the LGBT threads! This is a great idea, and I hope the Obsidian people consider a situation in the game that requires out of the box thinking. That said, if you were to create an impossible odds scenario, there would either have to be plenty of pre-warning or a quest specific NPC companion as a guide that basically tells you, in no uncertain terms, that a frontal assault will only end in defeat. Even with such contrivances, you would have people missing the point and raging about it on the forums.
Still, it would be great to try to do something along the lines you describe.