My impression is that different cultures will have different gender roles. Like in New Vegas things in the NPR seemed (on the surface) to be pretty equal but Caesar's Legion had strict roles for men and women- which, as an outsider, the courier was unaffected by (except the guy in charge of the arena wouldn't let women fight, because women are not fighters). I'm expecting more along those lines.
Gromnir brought up Arcanum and in that game I felt like I was being punished for playing a female character. So, yeah, no more of that please.