Really glad Obsidian is talking about logistics. I tried to sell my friends on supporting the kickstarter, but either they felt like they didn't have the time for a big single player RPG anymore but one had a game ending bug in an Obsidian title and were still sore over it. I know Miyamoto's Maxim ("A game is only late until it is released, but bad forever.") is less and less true in the modern era, but I'd like to give them my spare copy of Project Eternity and gloat at them having a "bug free" Obsidian game in their hands.
Anyway, as to the content of the post, you can add content to content light areas by moving semi-scripted events into unintended lulls. Stumbling onto another adventuring party in the woods or in a connecting cave could be interesting. I'm just a little worried about finding areas that I only ever visit in transit. I quit BG2 once after touring Athkatla looking for an (I can't remember what) because I realized I had been travelling and seeing loading screens for ten minutes straight.
Other, more minor concern: I know that they've obviated the need for this by promising that the game will be moddable, and thus the modding community will do it if Obsidian doesn't, but I note with some dismay that Obsidian has not yet committed to romance subplots (hereafter referred to as, "smut"). As one of those weird creatures that went to BioWare for equal parts interesting tactical decisions and smut I'm still hoping.