I'm all for vampires and werewolves as long as they aren't all mad/crazy killing machines.
Look up Vampire: the masquerade (not the game itself though it wasn't a bad representation of the books/pen & paper rpg it came from), those vampires had an agenda. Some were complete loonies with insane ideas of morality (usually the older ones who had very weird views which they had because they lived more then a 1000 years) , some were apathetic, some searching for a way out of their curse, some just trying to get as many kicks out of this as possible since they were doomed already, ... . Diverse lot those guys, they present a lot of story opportunities, I wouldn't mind having one or more of those as allies (not a companion) or as enemies (I still remember bodhi from baldur's gate 2). Was also fun that they acted only at night.
Werewolves also have something like that, werewolf the apocalypse. I personally thought the shamanism part there and the raving about mother nature wasn't particularly fun but they are so much more as well.
Just saying they can have an interesting story as well, they don't have to be monsters who storm at you with punishing attacks (level drain *shudders*)