I am female and I will not be buying this game. But...not because there is no choice of gender. I simply do not like "secret agent" stuff, never have. My husband used to love all the James Bond et al movies, no matter how many times they were on TV, he would watch them!
I do prefer RPG's where I can play as a female, but it won't stop me from buying a game, if it sounds interesting to me. (I loved PS:T, for example.)
I really enjoy science fiction/horror, but there are few to no RPG's in this particular catagory, (but there's shooter after shooter) so I had been looking forward to Aliens. (Sigh) And, personally, Mass Effect was a huge disappointment in the RPG department, even though it was sci-fi.