reload closest save after failure are the basic instinct of player
the problem is what cause the failure
is it obvious to the player
what player can do to make a difference
if the enemy are too strong then come back again after a few level up
if this boss have high acid damage then use protection spell accordingly
in the case of rolling 1 on a skill check
there is nothing to do other then roll again
as design for video game
it doesn't work