I have been having the exact same problems. Couldn't even get past character creation section of the game. The game hard crashes, with a black screen and looping sound (no Windows error or anything in the PoE log), forcing pushing the PC's reset button.
System is an i5 760, R9 390, Win10 x64 (April update), 16 GB RAM. Screen Res 1920x1200 (16:10).
After trying all the usual (older GPU driver, graphics settings, fullscreen and windowed modes etc), I was able to "solve" it by switching to 1280x720 windowed mode, which provides rock stable gameplay. I now suspect that the non 16:9 screen resolution might be the issue? Anyway, try 1280x720 windowed and see if that works for you also.