You have no experience with any kind of RPG at all? (If you do have some experience, you may prefer one play style over another.)
In terms of straightforward to play and not getting crushed, I would recommend a single-class Fighter, no subclass. They're tough and flexible. In general, for your first play through you will want to avoid multi classing and sub classing. Once you've used and understand the base capabilities, you can better decide how to mix-n-match them (multi class) or trade them off (sub class).
In the classical RPG genre, there was a "holy trinity": a tank, a healer, and DPS (damage-dealer). The tank is tough and tries to get opponents to focus on them. The healer keeps the tank -- and everyone else -- alive with buffs and heals, and the DPS adds damage into the mix because the tank often trades off damage-dealing for toughness and survival.
You start the game with Eder as a companion, and you can class him to be a Fighter (which he was in PoE 1) -- i.e. a tank -- or a Rogue (DPS), and in the first town you can get a priestess to join your party and she can be classed as a Priest (healer) or Monk (DPS). So you could chose to be a Fighter, class Eder as a Rogue, and keep the priestess as a Priest. (Now that I think about it, she may be less capable of healing, due to her religious orientation, than some Priests.) Or you could choose to be DPS-oriented ("Striker" in PoE 2 parlance) or support, and have Eder be a Fighter and the priestess be a Priest.
You might also read about the energy source each class uses. Some classes start with an energy level and spend it down, others start with minimal energy and build it up, and others don't use energy but have limited skill counts.
One key thing you'll want to think about is AoE (Area of Effect) skills/spells can hit your allies unless they mention enemies specifically. Other games you may have played may or may not have this "friendly fire", so be aware when considering. I tend to always play a Mage/Wizard first in RPGs, but I shied away from a pure Wizard in PoE and Poe@ because many of their best spells can put a serious hurt on friends as well as foes. (You can cast the spells to avoid friendly fire, but you might not be able to fully use the power of AoE, and it's also possible that your in-motion team-mates may step into your fire.) Just something to think about.