One minor tip Ive been using a lot in my PoTD runs is if you hover over each enemy the character they are targetings retical will change so you can identify who is about to get incoming damage.
It makes it easier to identify might need some pre-healing hots. Helps the most at the start of combat. Wish I could say I always remeber to do this but its all a learning curve.
Hope it helps and good luck!