If a vintage hardcore cRPG like this game sell well, then Obsidian should be able to make more of it.
The company has been burned so many time by now, I wouldn't blame them for being cautious with their next game. I just hope that the people at Obsidian manage to keep up with producing quality RPG content like they have been producing for the last few years. And in today's industry, they are like the last few people of ye olde RPG days who are still working on new games (Bioware is another).
You can blame publishers, other game genres or "social awareness", but at the end of the day, if a company can't make money off doing what they were doing before, then it's natural they turn elsewhere in order to keep running. It's the sad truth of business.