Don't care, the game should tell me.
I love mathematically complex games, they're fun to figure out and play with. However, I'm most likely in the minority, and the complexity is largely vestigal to actual gameplay - if you can make a simple game mechanic be as fun and balanced as a complex one, you'll ensure that more players are satisfied than with a complex mechanic. Simple mechanics are also easier to design and balance, leaving the devs with more time for other important stuff (and time is what Obsidian often needs, judging by some of its games). Thus, I'm happy either way, as long as I can make an informed decision with the game's aid. Making it without the game's aid is nice, but not essential.
Substantial, none.
That's easy enough. As I've mentioned, I love playing with complex mechanics, and to do that properly mechanic transparency is required - the more, the better. Lack of character skill shouldn't obstruct that, since it's the player who's interested in the underlying maths, not the character.
Essentially none.
Refer to the explanation on the first point. Gameplay takes precedence over comprehension.