I like the idea of crafting in games, but I think it could be handled better than it usually is. Sometimes it's superfluous (as you only make things you don't need or can easily buy or find,) or it's too labor-intensive (it's a must-have to get the best equipment in the game, and so takes up a lot of time scrounging for materials, etc.) I'd love it if we could find a third option, one that was included for and focused on fun and enhancing the game experience.
Is crafting something that is independent of class, build, and level-advancement, so everyone does it equally? Then I'd love to see crafting be used for unique, rather than powerful, things like extra bits of fun equipment not found anywhere else, upgrades to already-found equipment, frequently-used potions, and maybe a quest or two where you have to aid a master crafter make those super-powerful weapons.
Is crafting something that must be invested in as part of a build, with alternate crafting options (alchemy, blacksmithing, etc.?) Than I'd love to see crafting be a true potential build-focus, where instead of just supplementing your 'true' build with extra options, you could actually make crafting an intricate part of your approach to the game. Something like using alchemy to make and use powerful bombs and healing potions, using blacksmithing to improve your equipment before a fight, with fun, new options like using sculpting to create statues you can animate with magic to be grunt soldiers, or opening a shop in your house that added depth to the game with extra quests. I don't know what would be completely outside the scope of this game, but I always thought I'd love to see a modern RPG where we were truly given free reign, able to sail ships, craft siege engines, run a shop or fortress, make powerful items, etc as we saw fit as central options, rather than superfluous add-ons. I'd love to see this game not only let us be a fighter, thief or mage, but also an alchemist, a builder, an enchanter, or artisan as an equally-viable and alternate build option. I'm not that familiar with New Vegas crafting (as was mentioned above,) but maybe you could even have a mechanist crafting character, where they really do take whatever strange things they've found and turn them into useful items.
Perhaps that's only a pipedream, and it's obviously very inspired by the 3rd party Artisan Class from Pathfinder, but still it seemed appropriate to bring up here. More information on crafting and enchanting in the game would, of course, be appreciated.