Ran into my first serious bug, and it's a doozy. I can't work for Mr. House - all his bots go aggro when I enter the Lucky 38, even though I was invited there. It seems to automatically list me as having sided against him, though I never made that choice. It doesn't ruin my playthrough (I was leaning towards Wild Card anyway) but still, hopelessly broken critical path quest 25 hours in! **** you, Pop! That's what Josh is saying right now to me, in my mind.
From what I can tell the issue may be something to do with Victor the Cowbot - When I enter the strip for the first time I run into a Securitron that has Victor's face and talks like him, but when I leave dialog it switches back to the cop face (the bot's also named "Securitron MkI" instead of Victor). Victor's lifeless robocorpse is lying on the steps leading up to the 38, but when I enter, Victor is there and he's out for blood.
(this is on the 360. I might have been able to fix it via console on the PC)
*edit - Turns out this is a thing that got fixed, but you need a save from before going through Vault 11. I did that over 12 hours ago in game time, and I have no saves from that point! Sad faces.