You have my vote for SciFi or Space Opera. I'm in the middle of a Dune / Starship Troopers reading-kick, and I would love to see something to that effect.
Since the Eternal Darkness reboot seems to be stalled, I'll go ahead and say I would love to see an Eternal Darkness nod in the Infinity engine. Doesn't have to use the same mechanics or even imitate the gameplay, but really anything exploring Lovecraft's mythos would be dope, so to speak.