In quest mode, I had the rogue temporarily close a location (it was the last location to be closed).
The close requirement was to defeat a Poison Trap henchman. After I defeated the henchman, the wildcard "When you defeat a henchman, roll 1d6. On 1,2,3, discard the top blessing." was activated. I rolled a 4 after which the game did not continue and the only option was to forfeit. The Poison Trap was still showing as a small card in the top left corner, but the screen otherwise remained empty of cards. I could still switch characters.
General
Android
Android 6
Nexus 9
Gameplay
No pass & play, no permadeath
Quest mode
Barbarian, wizard, rogue, cleric (rogue temporarily closing)
Tier 1 hard, wildcards: the one mentioned above, and "when you fail to acquire a boon, discard the top blessing."
No character aided the check.