Should there be diseases in PE, and if so how should they work? Should a disease be permanent until cured, or should you be able to rest it off? Should there be only one disease effect, or many different ones? What should the effects be?
Possible durations of disease:
1. Duration of combat - I dont think this works logically, you should at least have to rest to get over an illness
2. Persistent until resting - this is how most disease should work as its the simplest solution, imo
3. Persistent until resting a certain number of times - im not sure how workable this would be as it would encourage rest spamming
4. Permanent until cured - this might be too annoying to deal with, but it could work as part of a quest
If there were more than one type of disease in the game, they could cause many different effects such as slow, attribute penalties and HP damage.
Diseases could have a life cycle where the penalties start small, then grow larger over time (presumably until resting)
Diseases could be contagious, spreading to nearby characters (or monsters)
Diseases in PE could also be spiritual, affecting your ability to access your soul powers
Different races could be affected by their own special diseases, or react differently to the same disease
How would disease have affected the cultural development of the populations of the world? In our own history, disease has been the deciding factor in many large scale troop engagements, changing the outcomes of wars and even the very course of civilizations. With no magic healers in the game, disease will likely have had the same impact on the world of PE. A lot of scientific examination of diseases will likely have taken place by some cultures of the world.