I might be alone on this but Shadow Run: Returns biggest downfall was the lack of romancing Cherry Bomb haha.
In all seriousness though, as a Game Design student I have new insight on the day to day tasks and problems that game development has. That said Obsidian has seemed to have very few according to the updates I have read. So they might be squishing the problems as fast as they rise. At any rate I don't have too many worries about the game itself. My primary hope for it now though is to have a nice meaty Campaign. Perhaps 40 - 50 hours before the mega dungeon? Might be asking a bit too much but SRR kind of side swiped me with the sudden end of the main campaign. I still enjoyed it though.