I don't really care about the setting of the game, just do whatever strikes your fancy, though if I were to pick one, I'd like either:
* a classic cyberpunk-ish setting, with extremely fast-firing guns, megacorporations, dehumanization through implants and weird drugs,
* a fin de siecle setting, where the plot revolves around an expedition to foreign/unexplored lands. This one could have fantasy elements, like portals to another dimension, tribal magic, stuff like that. It'd be all about the clash of the imperial 'western' civilization (or a version of it) and the unknown cultures of the unexplored land.
I also don't really care for the turn-based combat - real-time with pause would be enough for me. But I'd like an option in which I can go make myself a sandwich, return to the computer screen and carry on with the genocide while enjoying the delicious sandwich.
I don't need fully voiced dialogue - I can still read.
What'd really matter to me though, is compelling writing/storytelling and a significant role of choice and consequence. I would love to have to make several different character builds to be able to explore all quests, all quest outcomes and all locations. I would like the game to differ depending on whether I play a saintly fool or an evil bastard. I would like to experience the consequences of my actions, not only in the ending slideshow, but during the game even. And I would like to see a faction system, similar to what you did in New Vegas.
I'm convinced your team has what it takes to deliver in all those respects, so I'm wishing you good luck and keeping my fingers crossed for this project. You can count on my pecuniary contributions, should you decide to go with it, as well as my buying the game when it's out.