I'm new to PoE2 too and playing in turn-based the first time (veteran difficulty). I haven't really tried real-time, so I don't know how it compares, but here are my few impressions:
- The "everyone gets one action, except for wizards" mechanics are a bit usunual. I'm not sure whether a "quick rogue", or "quick" anyone is even possible in turn-based, because it doesn't matter how fast or slow a weapon is, you get one swing with it (or two if dual-wielding). It also doesn't matter that e.g. firearms are slow to reload, because in turn-based reloading happens immediately after shooting, meaning you'll have your pistol ready for the next turn.
- Wizards get an obvious advantage, because a lot of their self-buffs (such as mirror image) are free actions, meaning they can buff with everything they have in one turn.
- Scroll spellcasting is very powerful, because spells from scrolls are cast immediately, while most offensive spells cast from spellbook take some time to fire. And since you can increase damage of scrolls with arcana... I've ended up retraining my party wizard, filled his book with self-buffs and weapon summon spells, and just gave him a bunch of scrolls. Including druidic spells my druid doesn't even have access to yet.
I don't think I have enough of experience to recommend a build, but because of the above I'd not be surprised if a wizard/rogue is very powerful offensively in turn-based. You get a wide arsenal of abilities to use, provided you invest in arcana and craft scrolls. Whether you could consider them a glass-canon depends on whether you'd use wizard buffs, though.