I remember my first playthrough when I went to the Great Oak lab with no armor and just basic weapons I ran past like three spiders straight inside to escape, after I was safe and talked to the robot I went back thinking they were gone, they weren't. One was able to glitch inside and kill me but since then I've learned and found a few tips to help kill spiders that I've written in my article
[Top 5] Grounded Best Way To Kill Spiders