Well, I actually will love a Pathfinder based CRPG from Obsidian (or at least Bioware, no others).
I will also love a World of Darkness (in particular Vampire: The Requiem) CRPG from Obsidian (I'm praying on my knees for this one), for a great sequel to Vampire: Bloodlines, one of my all-time favourite, from another great company at making CRPGs, now departed Troika Games!