Firstly, I hope that all at Obsidian affected by the fires in California are safe and sound.
That said, I made a post for the 0.3.0 PTB that as of that version, I was having immediate CTD situations, and could find no workaround. The patch launched and the problem persisted. None of the subsequent hotfixes remedied this problem, but I was very hopeful that after about a month of not even being able to launch the game, this would be resolved. Imagine my sadness upon downloading the current PTB and finding that the situation is, in fact, still present. I've checked all drivers and whatnot,