Running Win7x64. I have 3 monitors. all same resolution - 1600x900 (not max resolution for 2 of them).
GPU is Nvidia gtx 1080
Game initially started taking up the right half of left-hand monitor, all of middle monitor, and left half of right-hand monitor. It looked like it was expecting there to be 3 more monitors below mine. I got that closed. Started again. This time, monitors flicked between black screen, desktop, a very low-res version of windows 7 desktop (without my icons) and black screen again. Game never appeared and no music.
Then I came here and learned I'm not only one having problems and saw the trick for Alt-Enter.
Started game again and tried it. No luck after about 5-7 seconds. Then about 10-12 seconds in I keyed it in again and this time the game screen came up. But this time, as before, it was spread over half of left monitor, all of middle, and half of right monitor. But this time it was not descending down to where I couldn't click on anything. So, I changed resolution to 1600x900x59hz. This works for me and my set up.
However... good lord.. .takes 50 seconds after clicking the PoE2 shortcut to get to the actual game screen. 50 seconds of dark monitors (all 3 monitors). But game only plays on the center - as I want it too. I play fullscreen. Sometimes the game loads and the 2 side monitors are dark. Sometimes they aren't and show desktop.
Playing in windowed mode at 1366x768 brings up the Game Window..... but the window stays complete white and my mouse goes in to circle mode. Again, it takes 50 seconds before the game comes up to Obsidian game logo. ... oh and while in windowed mode,.. I can't minimize the window. I click on the dash of the window for minimize and it thinks I've clicked in the game window. Thus, I have to close game every time I need access to my desktop.