Yeah, I'd rather see true multi-classing or perhaps just "kits" for the existing ones, or both, than new classes. All the bases are already covered really, but hybrids are always fun.
I love Bloodlines and still replay it every so often, I'd love to see a sequel (Hell, I'd like a sequel to Arcanum and TOEE too!) I don't know if they'll make a direct sequel to it but definitely something in the WoD universe. I've been trying to be patient following the news the IP was sold but its hard after waiting years for the WoD MMO to go bust! Though, there is a good looking game in the works that isn't in the WoD universe but very similar: http://dogma-universe.com/en/