If I had my druthers, they'd find some arid region accessible to both the Vailian Republics and Dyrwood and use it to stage a fantasy Western during a sort of hybrid Manifest Destiny/gold rush scenario. Would be a nice opportunity to see what kind of classes they could come up with if they weren't going for Forgotten Realms nostalgia. Revolver-toting spellslingers, mystic gamblers armed with enchanted tarot decks and luck based abilities, scalp-collecting Glanfathan reavers or shamans with animal spirit guides... if nothing else, something less boring than fighters and paladins.
It would also be an ideal setting to replace the stronghold concept with something that works more like Oregon trail -- managing a caravan, fixing wagon wheels, buying supplies (to cut back a bit on rest spamming). Probably not dying of dysentery, but maybe you could still pick up long-lasting afflictions. You could also probably cut down on the weird Adventure concept from strongholds by just giving non-party companions a lot of non-scripted, mechanical ways to use their time -- guarding the camp, practicing skills, training other characters, crafting items, healing the injured, hunting, using their skills to earn money in town.