Some questions that I've not seen asked yet:
1. Will we be able to purchase upgrades for the Ebon Hawk?
2. Will the swoop bikes also be upgradable?
3. Will there be new mini-games?
4. In Kotor1, your party members seemed to be little more than additional combat sheilds. In Kotor2 will we see more use of the NPC's individual skills or perhaps knowledge? For example, a NPC that has complete or partial knowledge of a base and a method to bypass certain combat hotspots or be able to lead you to a little known cache of items? NPC's with skills at a much higher level than the PC has thus making them critical in certain party situations. If you are going to have the NPC's be able to 'create' items, it would be nice if the creation process actually took some game time (so you don't have things being made right on the spot).
5. Hopefully it will be easier to move items from inventory to containers than it was in Kotor1. More and better stacking would be nice also. Anything that is the same should stack.
I also like the earlier suggestion about modifing the 'Last man standing' rule. Just wanted to add my vote.
I also would like to add my vote to having opponents more wary of you or run away or surrender when the battle turns against them. It would be refreshing to NOT have to always kill every moving thing in a combat situation once combat starts.