In the very first area where you see the dark priest and 3 disciples infront of the ancient relic. 

If you keep pressing esc to skip the scene it results in the sound progressing but the scene it self to stall.

The game it self does not crash as you can still see the movement in the Dark Priests robe. But the sound continues forward but the rest of the animations besides the robe are stalled [ The temple - the soul sucking rays - etc ] 

Yeah i've been having the same problem, though it seems to happen even when i don't press esc.

The game hangs for me at that point on OS X and I can't get past it.