As we know, there are knew challenges coming up that include inability to pause the game, or slow down the game. Is it possible for someone to code a hotkey component to have faster reaction times? So there wont be the tedious point click point?

This capability already exists, though I don't know how all encompassing it is. I only discovered this accidentally when taking a steam screenshot.

 

Hover over an ability and press a key to assign a hotkey.

'sides, challenges won't work with mods anyway