@Roby, the issues are both in the character creator as well as the game itself. As per my previous posts, any item the main inventory is opened (on the player's character), as well as any time an item is switched out on one's avatar, the game will lag for a good 10-15 seconds. The audio/VO delay is constant with any interaction.
A little update as well: I was experiencing this inventory/portrait/VO delay problem without having Hamachi installed so I did a little investigation. My motherboard has two built in ethernet devices, one an Intel and another being a Killer Ethernet E220x device. Applying what was learnt here on this forum and my previous experience with Kerbal Space Program, I reconnected to my network via my Intel port instead of the Killer and disabled the Killer within Windows. As soon as that was done, the problems within Pillars of Eternity were gone and any delay as well. There seems, in addition to Hamachi, to be an interface problem between Unity/PoE and Killer Ethernet cards as well. Thought I should mention this if anyone else has a Killer NIC as well. Hope it helps any users as a temporary work around and any devs with a solution!
Kind regards.