Low fantasy, in a non-Medievalist way. The classical Maya era (With appropriate magic and mythos, of course) would work perfectly, particularly the competitive city-state oriented world, ancient rumored civilizations, and a plethora of culture clashes would fit the genre perfectly.
Other than that, I can imagine a stat-based, non-linear platformer that's not Japanese. Being set in a bizarre, cartoon-ish world like The Neverhood would definitely help.
A sandbox-y sort of decaying dystopia setting would be perfect, especially if it's paired up with lots of transgressionalist themes, particularly if it's inspired by Fight Club. Having a Tyler Durden-esque NPC as your mentor would be surrealistic beyond belief.