Modern World (cars, celebrities, politics, corruption, etc) + Fantasy World (magic, elves, gnomes, etc) + Dark settings
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I noticed someone mentioned an Arcanum sequel. As far as I know, the IP belonged to Sierra (belongs to Activision now), so you probably can't make an Arcanum sequel.
But I think an Arcanum like game in future is a good idea. If you have played Arcanum, you know that in one of the endings Arranox returns to Arcanum and turns it into a land of technological marvels. Something like our own world, with cars and airplanes and bikes, but with magic, and elves and orcs and fantasy creatures. I'd love to see an elf hippy or singer or rapper, or a half-ogre bounce in a night club, or a gun wielding magic user who drives a fast car, or a billionaire gnome who runs a big computer company and ...you know, fast forward Arcanum 500 years and you get it. A combination of our own world and a fantasy world, a place which seems familiar and alien at the same time, with a dark setting, of course.