I am experiencing the same issue since the turn-based patch, though my Game only crashes when entering any cutscene or forced dialogue (as in not started by me). The screen freezes and sound hitches for a second. Sound then continues, i can move the cursor and it will react and I can advance conversations but nothing happens in terms of visual display.
Radeon WattMan also then reports an "unexpected failure", so assume it has something to do with graphics. I am running an R9 390, which usually does not run into any problems.
So far I have:
1) Turned Vsync On/Off
2) Turned GoG overlay On/off
3) Tried Windowed/Fullscreen
4) Updated Graphics Driver
5) Clean Re-Install of Graphics Driver
6) Clean Re-Install of PoE II
7) Tried running the game with my 2nd screen unplugged.
I am really at a loss here. I restarted my playthrough in turn-based mode and it worked fine for a good long while. First crash happened with the cutscene after finishing the Questline with the feuding families in Neketaka. I thought it might be a problem with that specific moment, reloaded and moved on. Now I am at Fort Deadlight at can't go up to the smithy, because the game crashes once the guard talks to me. On my previous, non turn-based, save this cutscene worked fine.
I'm grateful for any ideas on what I could do, because I really want to play through this game.