I'd love to see the PoE style CRPG used in a non-fantasy or post-apocalyptic setting.
I'd think one of the following would suit the style nicely:
Wild west, sci-if (Star Wars-ish), modern day super hero (if you could pick up the Freedom Force IP that'd be amazing!), or while I'd like to think Alpha Protocol crpg I can't see spies traveling with a bunch of constant companions. But paramilitary with fantasy/sci-fi twist (think Predator but clearly with a ton more foes)