I am trying this as well (on POTD) and I guess there are only two choices due to +speed buffs - Monk/Wizard and Barbarian/Wizard. Unfortunatelly due to fact that monk's passive unarmed skill doesn't apply to Ogre fists, so monk's fists will be stronger than ogre fists after few levels. Also Ogre fists have pretty low armor penetration, so I guess that berserk/transmuter is better (Tenacious adds +2 armor penetration). In both cases I guess you have to max out Int (for duration) and Dex (for speed). Edit: So at the end I think the best choice is Barbarian (no subclass)/Transmuter. Penetration from Tenacious probably doesn't worth the damage you take from it (for this build). Dps of ogre is definiitely lower then dps of other builds, but it's playable even on POTD so far and I like it. )