Hi there! This is my first play-through and I've been enjoying it a lot so far.
One not-so-minor issue:
I keep getting mobs that either hit for insane amounts of damage (ie. skeleton that hits for 700-1000) or mobs that have insane defenses (218 on an Animat, screenshot: http://postimg.org/image/5reabb6x9/.)
From looking around, this seems to be some sort of a duplication issue on frequent saving. I'm told a full save/re-load should fix this but nothing I've done so far has worked.
I managed to get around the insane skeletons because they died easy and could be CCd. This animat is completely unkillable though. =/