End-game spoilers ahead, but nonetheless important for the developers to see I think.
I'm in Byzantium at the moment, and for whatever reason the Early Retirement quest dipped my reputation with the Board over the edge. Now everyone guard in Byzantium wants to kill me and every citizen runs from me. This is unacceptable, as the end-game necessitates that you be in Byzantium. My enjoyment is almost ruined by this, since I couldn't take my way in or out of situations as I've done the entire game. The impact of being hated by a reputation you are forced to interact with shouldn't be shoot on sight - quite frankly, it's nearly game-breaking.
Obsidian, I hope you find some way to fix this, because I don't want to experience, say, DLC, where everyone hates me. It would be really unfortunate.