Been having the same issue as well. Running the game with Steam in Administrator mode, without the overlay, without cloud syncing, and numerous other 'suggestions' mentioned in another thread did nothing to fix the issue. I've gone into LocalLow to delete the Obsidian folder there as someone suggested, but nothing. Only thing I can imagine is that there is something intrinsically screwy about the Saved Games folder under Users/%CurrentUser%/ that is acting this way...
Further, to add onto this; I've noticed that while the game SOMETIMES auto-saves, when trying to load them, the file becomes corrupt and basically freezes the game. When closing the game and returning to it as well, the save files either automatically wipe themselves somehow, or remain corrupt, forcing me to start a new game each and every time I play.
This has made things utterly unplayable past the first zone...and there's only so many times you can go pick berries and kill the ruin's protectors before you wonder what you're doing playing the same 20 minute segment of the game...over and over and over again hoping to somehow beat this obvious bug.
